Sepsis was defined by The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) in 2016 as "life-threatening organ dysfunction caused by a dysregulated host response to infection" .
Septic shock forms a subpopulation of the sepsis cohort, manifesting as synchronous severe cardiovascular, cellular and metabolic dysfunctions, linked to an elevated risk of mortality, versus sepsis alone .
Establishing the diagnosis of septic shock in adult patients requires that despite satisfactory fluid resuscitation there is:
- serum lactate >2 mmol/L
NB The separate condition "severe sepsis" has now been abandoned. "Septicemia" is generally not felt to be helpful any longer due to it being too narrow in scope.