serous adenocarcinoma of cervix

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A papillary serous carcinoma of the cervix (PSCC) is an uncommon histological type of cervical cancer. It is considered a sub type of adenocarcinoma of the cervix.

Epidemiology

Accodring to some studies, there was a bimodal age distribution, with one peak occurring before the age of 40 years and the second peak after the age of 65 .

Pathology

Papillary serous adenocarcinoma of the cervix resembles microscopically its counterparts elsewhere in the female genital tract and peritoneum.

Markers

PSCC may give a significantly higher p53 and lower CEA reactivity than other more common histologic subtypes

Staging

Staging is same other cervical tumors - see - cervical cancer staging

Treatment and prognosis

These tumors can behave aggressively with supradiaphragmatic metastases and a rapidly fatal course when diagnosed at an advanced stage, but the outcome for patients with stage I tumors is similar to that of patients with cervical adenocarcinomas of the usual type .

The following factors have been associated with a poorer prognosis

age <65 years at diagnosis
stage > I
tumor size > 2 cm
tumor invasion > 10 mm
presence of lymph node metastases
elevation of serum CA-125

In contrast to ovarian, tubal, and endometrial serous carcinomas, local therapy appears to be effective treatment for many serous carcinomas of the cervix .