adenocarcinoma of the cervix

Adenocarcinoma of the cervix is a histological subtype of carcinoma of the cervix.

Epidemiology

Cervical adenocarcinoma is less common than squamous cell carcinomas (SCC) of the cervix, accounting for ~12.5% of all cervical cancer. Their proportionate prevalence is thought to be increasing and this is thought to be due to being less readily detected by exfoliative cytology obtained with the Papanicolaou test .

Pathology

As with squamous cell carcinomas, adenocarcinoma type also generally tend to arise from the squamocolumnar junction (SCJ). They may arise from a precursor lesion, cervical adenocarcinoma in situ, and are almost always associated with HPV 18 .

Risk factors

Aside from smoking, cervical adenocarcinoma has the same risk factors as cervical SCC (see: cervical carcinoma for further details of risk factors) .

Classification

There are several subtypes that fall under this category and include:

• clear cell carcinoma of the cervix
• endometrioid carcinoma of the cervix: ~7% of adenocarcinomas 
• mucinous carcinoma of the cervix
  • adenoma malignum: ~3% of adenocarcinomas
• serous carcinoma of the cervix
• mesonephric carcinoma of the cervix

Adenocarcinomas in general (compared with squamous cell counterparts) are thought to generally give higher rates of thoracic and adrenal metastatic disease .

See also

• WHO histological classification of tumors of the uterine cervix

Siehe auch:

• Zervixkarzinom
• WHO histological classification of tumours of the uterine cervix
• clear cell carcinoma of the cervix
• mesonephric carcinoma of the cervix
• Plattenepithelkarzinom der Zervix uteri
• Adenoma malignum der Zervix uteri
• mucinous carcinoma of the cervix
• endometrioid adenocarcinoma of cervix
• serous adenocarcinoma of cervix

und weiter:

• adeno squamous cell carcinoma of the cervix
• papillary serous carcinoma of the cervix
• endometrioid carcinoma of the cervix