St. Anne-Mayo grading system of astrocytomas
The St. Anne-Mayo grading system, also known as the Daumas-Duport grading system, introduced in 1988 was for a time a popular system for grading diffuse astrocytomas but has now largely been replaced by the WHO grading system which is, however, derived from the St Anne-Mayo system and thus shares many similarities .
The St. Anne-Mayo grading system is a 4 tiered system and uses the presence of 4 morphologic criteria to assign a grade:
The grade then depends on the accumulation of these criteria as follows:
- grade 1: 0 criteria
- grade 2: 1 criterion (usually nuclear atypia)
- grade 3: 2 criteria (usually nuclear atypia and mitosis)
- grade 4: 3 or 4 criteria
Note that unlike the WHO classification, Roman numerals are NOT usually used.
History and etymology
Named after Catherine Daumas-Duport, a French pathologist from Sainte Anne hospital who also worked together with the Mayo-Clinic in the United States.