WHO grading system for diffuse astrocytomas

 The WHO grading system is the most widely used system for grading diffuse astrocytomas (at the time of writing i.e. mid-2016) and is an adaptation of the now superseded St Anne-Mayo grading system (also known as the Daumas-Duport grading system).

Grade I is reserved for localized astrocytomas (see WHO classification of CNS tumors for a complete list) and as such diffuse astrocytomas range in grade from grade II to IV.

Gliomatosis cerebri does not have its own grade but rather is a highly infiltrative version of a low grade or anaplastic tumor which involves at least three lobes . It does, however, confer a worse prognosis.

It is worth noting that there are other grading systems (see diffuse astrocytoma grading) and the pros and cons of each have been the subject of extensive debate.

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