Stewart-Treves syndrome refers to an angiosarcoma seen in the setting of lymphedema .

It was classically attributed to lymphedemas induced by radical mastectomy to treat breast cancer. Nowadays, we know that it can arise in chronically lymphedematous regions of any cause .

The incidence is unknown, but studies have shown that it occurred at a rate of between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy .



It can arise from any cause of chronic lymphedema :


Chronic lymphedema seems to induce a degree of local immunodeficiency that leads to oncogenesis .

Treatment and prognosis

The prognosis is very poor because angiosarcomas are very aggressive tumors that frequently recur locally and often metastasize early.

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