Stewart-Treves syndrome

Stewart-Treves syndrome refers to an angiosarcoma seen in the setting of lymphedema .

It was classically attributed to lymphedemas induced by radical mastectomy to treat breast cancer. Nowadays, we know that it can arise in chronically lymphedematous regions of any cause .

The incidence is unknown, but studies have shown that it occurred at a rate of between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy .

Pathology

Etiology

It can arise from any cause of chronic lymphedema :

• mastectomy induced lymphedema
• Milroy disease
• congenital lymphedema
• traumatic lymphedema
• filarial lymphedema
• elephantiasis nostras verrucosa
• idiopathic lymphedema

Pathophysiology

Chronic lymphedema seems to induce a degree of local immunodeficiency that leads to oncogenesis .

Treatment and prognosis

The prognosis is very poor because angiosarcomas are very aggressive tumors that frequently recur locally and often metastasize early.

Siehe auch:

• Angiosarkom

und weiter:

• breast curriculum
• angiosarcoma (MSK)
• syndromes with a vascular component
• Angiosarkom der Mamma
• vaskuläre Syndrome