Urothelial carcinoma with squamous differentiation

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Urothelial carcinoma with squamous differentiation (USCD) is a variation of urothelial cell carcinoma which is associated with advanced tumor stage. When occurring in relation to bladder cancer, around 60-70% of the cases occur in those with muscle-invasive bladder cancer (MIBC) .

Treatment and prognosis

Urothelial carcinoma with squamous differentiation tends to show more aggressive behavior, a higher risk of recurrence and worse survival outcomes when compared to pure urothelial carcinoma .