Fibrotic non-specific interstitial pneumonitis

Fibrotic non-specific interstitial pneumonitis is a histological subtype of non-specific interstitial pneumonitis (NSIP). It is considered the more common form . This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homogeneous pattern, and occasional focal honeycomb fibrosis .

Treatment and prognosis

Corticosteroid can be given but it carries a worse prognosis than the cellular type.

Differential diagnosis

The key imaging differential is a UIP pattern

  • according to one study 62% of patients with UIP showed subpleural predominance whereas 55% of patients with fibrotic NSIP exhibited random distribution
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