Serrated polyposis syndrome

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Serrated polyposis syndrome (SPS), also called hyperplastic polyposis syndrome, is one of numerous polyposis syndromes and is characterized by the presence of multiple serrated polyps or a mixture of serrated and hyperplastic polyps, with the exact number required for diagnosis dependent on location and family history.

Serrated polyposis syndrome has a heterogeneous genetic underpinning with BRAF and KRAS mutations being the most common, with an incidence of ~70%. Colorectal carcinoma may develop in up to 50% of patients.