BRAF (B-Raf proto-oncogene serine/threonine-protein kinase) is a proto-oncogene, encoding for a serine/threonine protein kinase. Mutations of BRAF are the most common alteration of the RAS/MAPK pathway and these have been identified in a variety of tumors and congenital syndromes including :


A variety of mutations are recognized, the most commonly encountered being:

  • BRAF V600E point mutation (most common)
  • BRAF fusion (KIAA1549:BRAF fusion)