Gastric varix

Fundusvarizen

bei Leberzirrhose mit portaler Hypertension. Computertomographie axial.

Gastric varices are an important portosystemic collateral pathway, occurring in ~20% of patients with portal hypertension. They are considered distinct from esophageal varices in that they have a propensity to hemorrhage at comparatively lower portal pressures , and are also associated with higher mortality rate with hemorrhage (range 14-45%) .

Clinical presentation

Patients may present with symptoms and signs of upper gastrointestinal bleeding or hypovolemia such as:

coffee-ground vomit
melena
syncope
shock

Patients will generally have a history of cirrhosis and may have other symptoms of chronic liver disease.

Pathology

Gastric varices occur due to elevated portal venous pressure, and represent a collateral flow pathway from the congested portal system to systemic veins. They commonly co-occur and may be continuous with esophageal varices .

The gastric varix itself usually represents a dilated left gastric or posterior gastric vein.

Afferent inflow is most commonly from :

left gastric vein
posterior gastric vein
gastroepiploic vein (rare) - mostly occurring after prior intervention

Efferent outflow is most common through :

gastrorenal shunt (to left renal vein)
- often communicates with small retroperitoneal veins
- may or may not communicate with the phrenicopericardial or intercostal veins
- rarely communicates with the ascending lumbar, vertebral plexus, or azygos veins
gastro-caval shunt (to suprarenal IVC)
- often communicates with the phrenicopericardial and intercostal veins
- rarely communicates with the azygos vein
fundus-inferior phrenic vein

Classification

The most common (Sarin) classification scheme characterizes gastric varices by their co-occurrence with esophageal varices and anatomic location :

gastric and esophageal varices (GOV)
- type 1 (GOV1) - at lesser curvature
- type 2 (GOV2) - at gastric fundus
isolated gastric varices (IGV)
- type 1 (IGV1) - at gastric fundus
- type 2 (IGV2) - other gastric or early duodenal location

In 2003, Kiyosue proposed a classification system intended to guide intervention by BRTO-type techniques. With this in mind, gastric varices may be characterized by inflow and outflow patterns:

Inflow pattern (following outflow occlusion)

Type 1 - stagnant varices flow
Type 2 - shifting flow between separate gastric varices
Type 3 - continued efferent flow via separate draining vein, despite occlusion

Outflow

Type A - drained by a single large shunt
Type B - drained by a single shunt + smaller collateral veins
Type C - drained by both gastro-renal and gastro-caval shunts
Type D - not continuous with a shunt (multiple smaller collaterals)

Radiographic features

CT

CT with intravenous contrast enhancement is helpful in confirming the presence of gastric varices and identifying their cause. Findings include well-defined clusters of rounded and tubular enhancing vessels. Other findings consistent with portal hypertension may be found .

Treatment and prognosis

Management of gastric varices is also distinct from esophageal varices due to the anatomy. Endoscopic clipping or sclerosing are typically first line treatments, although interventional radiology techniques such as TIPS and BRTO are important therapeutic adjuncts. Indeed, BRTO is first-line therapy for gastric variceal hemorrhage in some Asian countries .