adenocarcinoma in situ of the lung

Adenocarcinomas in situ (AIS) of the lung refer to a relatively new entity for a pre-invasive lesion in the lung. This entity partly replaces the noninvasive end of the previous term bronchoalveolar carcinoma. Adenocarcinoma in situ is defined as a localized adenocarcinoma of <3 cm that exhibits a lepidic growth pattern, with neoplastic cells along the alveolar structures but without stromal, vascular, or pleural invasion .

Pathology

AISs are localized adenocarcinomas of ≤3 cm, with no growth pattern other than lepidic, with neoplastic cells along the alveolar structures but without stromal, vascular, lymphatic, or pleural invasion, and no features of necrosis .

There are three histopathological subtypes, the most common is non-mucinous, with mucinous or mixed subtypes being rarely found.

Radiographic features

CT

While adenocarcinoma in situ is usually seen as a pure ground-glass nodule or a part-solid lung nodule, there can be overlap among the imaging features of atypical adenomatous hyperplasia, adenocarcinoma in situ, and invasive adenocarcinoma of the lung .

Nuclear medicine

FDG PET-CT

Adenocarcinomas in situ are commonly associated with PET false-negative results. FDG PET-CT is recommended when assessing subsolid ground-glass lung lesions that have a solid component measuring more than 8 mm .

Treatment and prognosis

Adenocarcinoma in situ carries an excellent prognosis, with reported survival rates of 100% following complete tumor resection.

For follow-up guidelines consider - Fleischner Society pulmonary nodule recommendations

Siehe auch:

• Lungenkarzinom
• Milchglasverschattungen
• Adenokarzinom der Lunge
• solitärer pulmonaler Rundherd
• Milchglasherd
• nichtkleinzelliges Lungenkarzinom
• chronic unilateral airspace opacification
• partly solid pulmonary nodules
• minimally invasive adenocarcinoma of the lung
• lung cancers
• atypische adenomatöse Hyperplasie

und weiter:

• Bronchopneumogramm
• lepidisches Tumorwachstum
• Konsolidierung der Lunge
• Kryptogene organisierende Pneumonie (COP)
• Bronchiolitis obliterans
• tree in bud-Muster
• kongenitale pulmonale Atemwegsmalformation (CPAM)
• adult chest radiograph common exam pathology
• differential of chronic alveolar opacities
• zentrilobuläre Lungennoduli
• chronic bilateral airspace opacification
• acute unilateral airspace opacification
• Lungentumor
• Chronische Lungeninfiltrate
• adenocarcinoma in situ
• bulging fissure sign
• minimally invasive adenocarcinoma of lung
• Thorax Onlinekurs
• CT angiogram sign
• bronchorrhoea
• pseudocavitation
• Klebsiellenpneumonie
• lung cancer bronchogram
• Schmetterlingskonfiguration von Lungenverdichtungen