amsterdam criteria for HNPCC

The Amsterdam criteria are used in the diagnosis hereditary non polyposis colorectal cancer (HNPCC).

Amsterdam Criteria I

Initial description in 1991:

• > or equal to 3 relatives with colorectal cancer (CRC)
• > or equal to 1 case in a first degree relative
• > or equal to 2 successive generations should be affected
• > or equal to 1 tumor should be diagnosed before the age of 50 years
• FAP should be excluded
• tumors should be confirmed with histology

Amsterdam Criteria II

Revision in 1996, and is one of the most widely used criteria at time of writing (July 2016) alongwith Bethesda guidelines.

• > or equal to 3 relatives with colorectal cancer (CRC) or with an HNPCC associated cancer
  • endometrial carcinoma
  • small bowel adenocarcinoma
  • ureter or renal pelvis cancer
  • ? 1 case in a first degree relative
• > or equal to 2 successive generations should be affected
• > or equal to 1 tumor should be diagnosed before the age of 50 years
• FAP should be excluded
• tumors should be confirmed with histology

An alternative criteria scheme is the Bethesda criteria of HNPCC

Siehe auch:

• Kolorektales Karzinom
• hereditary non-polyposis colon cancer syndrome (HNPCC)
• Bethesda-Kriterien für HNPCC

und weiter:

• hereditary non-polyposis colorectal cancer