Angiotensin converting enzyme (ACE)

Angiotensin converting enzyme (ACE) is a central component of the renin-angiotensin system (RAS) which assists in blood pressure control by regulating the volume of fluids in the body.

Normal individuals may have a small volume of the angiotensin converting enzyme circulating in their blood.

Measurement

Angiotensin converting enzyme is normally measured in nanomoles per milliliter per minute (nmol/mL/min) with normal range considered less than than 40 nmol/mL/min. Elevated levels may be associated with a number of conditions with the most notable being sarcoidosis .

Other conditions that have reported to be associated with higher levels of angiotensin converting enzyme include:

• primary biliary cholangitis
• alcoholic liver disease
• hyperparathyroidism
• hyperthyroidism
• diabetes mellitus
• multiple myeloma 
• lung disease
• amyloidosis
• Gaucher disease 
• leprosy