bartter syndrome

Bartter syndrome is a rare inherited renal disorder.

Pathology

Bartter syndrome is characterized by hyperplasia of the juxtaglomerular cells along with:

• hypokalemia
• metabolic alkalosis
• hypotension/normotension
• elevated plasma renin 
• elevate aldosterone
• antenatal polyhydramnios

Classification

There are two subtypes of Bartter syndrome:

• classic: presents in early childhood with polyuria, polydipsia with a predisposition to dehydration
• neonatal: presents earlier

History and etymology

First described in 1962 by American physician Frederic Crosby Bartter (1914-1983).

See also

• Gitelman syndrome: a closely associated disorder, milder than both subtypes of Bartter syndrome
• Schwartz-Bartter syndrome: a separate entity characterized by hypertonicity of urine, hyponatremia and inability to excrete water load

Siehe auch:

• Polyhydramnion
• Syndrom der inadäquaten ADH-Sekretion (SIADH)

und weiter:

• Diabetes insipidus
• Polyurie