Chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma is one of the less common subtypes of renal cell carcinoma (RCC).


This is the least common major subtype of RCC, occurring 5% of the time . Similar incidence in men and women.


This type of RCC arises from intercalated cells of collecting ducts . The designation "chromophobe" arises because the tumor cells are less translucent than clear cell renal cell carcinomas during staining for histology . They have a similar origin to oncocytomas .

Radiographic features

  • presents similarly to other renal cell masses, with an isoechoic/hypoechoic masslike contour abnormality and flow on color Doppler imaging
  • relatively homogeneous contrast enhancement
  • isointense to kidney / maybe T2 hypointense
  • relatively homogeneous contrast enhancement
  • necrosis not common

Differential diagnosis