The cingulate gyrus lies on the medial aspect of the cerebral hemisphere. It forms a major part of the limbic system which has functions in emotion and behavior. The frontal portion is termed the anterior cingulate gyrus (or cortex) .
The cingulate gyrus extends from the subcallosal gyrus in the frontal lobe anteriorly to the isthmus posteriorly. It follows the superior convexity of the corpus callosum separated from it by the callosal sulcus .
The middle and most horizontal portion lies inferior to the paracentral lobule separated from it by the cingulate sulcus .
Its posterior portion (posterior cingulate gyrus) lies inferior to the precuneus separated from it by the subparietal sulcus. Connections between the precuneus and cingulate gyrus are anterior and posterior to this sulcus. The posterior cingulate gyrus and isthmus lie anterior to the occipital lobe separated from it by the parieto-occipital sulcus .
The cingulate cortex is part of the limbic system and there is evidence that it has a role in emotion, attention and social behavior . Cingulate volumetric size and activity may predict response to electroconvulsive therapy for mood disorders, and abnormalities have been described in schizophrenia .