Cyclopia refers to a rare fetal malformation characterized by a single palpebral fissure and a single midline orbit. This orbit may contain either a single globe or two separate globe.


The condition is thought to affect approximately 1 in 40,000 to 95,000 births (inclusive of stillbirths)


It results from a deficient development of the superior precordial segment with an associated underdevelopment of the oro-nasal cavity . There is a severe error in prosencephalic development.


Cyclopia can also occur as part of the spectrum of

Possible associations

Radiographic features

Antenatal ultrasound

May be seen with targeted imaging of the fetal face where a common orbit may be seen in the upper half of the face.


Cyclopia is essentially incompatible with life .


Derived from the Greek word 'cyclopes' meaning 'ring-eyed' .

See also

  • synopthalmia