There is limited information on the incidence of eosinophilic endocarditis.
- the majority of those affected with idiopathic hypereosinophilic syndrome are male (estimated ~90%)
Eosinophilic endocarditis results from eosinophilic inflammatory infiltration of the ventricular endocardium. The inflammatory process eventually leads to local necrosis and endomyocardial fibrosis .
Intraventricular thrombus commonly forms as a result and often contributes to heart failure by impairing diastolic filling and ventricular function .
Improved detection is impacted by the use of a multi-modality investigation, including the use of transesophageal echocardiography and contrast agents. The standard transthoracic echocardiogram will typically reveal the following features, which are characteristic of the restrictive cardiomyopathies:
- normal left ventricular systolic function
- normal LV cavity dimensions
- diastolic dysfunction
- biatrial dilation
Features which are specific to hypereosinophilic syndrome include :
- left ventricular apical obliteration by laminar thrombosis
- thickening and increased echogenicity of subendocardial structures
- preferential involvement of the left ventricular posterobasal (inferolateral) wall and posterior leaflet of mitral valve
- consequently restricted excursion of mitral valve's posterior leaflet
- eccentric mitral regurgitation
History and etymology
It is named after Swiss physician, Wilhelm Löffler (1887-1972) .