Eosinophilic endocarditis

Eosinophilic endocarditis, also known as Loeffler endocarditis, is one of the cardiac manifestations of idiopathic hypereosinophilic syndrome. It also considered a form of cardiomyopathy.


There is limited information on the incidence of eosinophilic endocarditis.

  • the majority of those affected with idiopathic hypereosinophilic syndrome are male (estimated ~90%)


Eosinophilic endocarditis results from eosinophilic inflammatory infiltration of the ventricular endocardium. The inflammatory process eventually leads to local necrosis and endomyocardial fibrosis .

Intraventricular thrombus commonly forms as a result and often contributes to heart failure by impairing diastolic filling and ventricular function .

Radiographic features


Improved detection is impacted by the use of a multi-modality investigation, including the use of transesophageal echocardiography and contrast agents. The standard transthoracic echocardiogram will typically reveal the following features, which are characteristic of the restrictive cardiomyopathies:

Features which are specific to hypereosinophilic syndrome include :

History and etymology

It is named after Swiss physician, Wilhelm Löffler (1887-1972) .

See also