Gadoterate meglumine

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Gadoterate meglumine (also known as gadoteric acid and by the tradename Dotarem) is an intravenous extracellular MRI contrast agent.

  • cyclic, ionic molecule 
  • 100% renally excreted
  • T1 relaxivity at 1.5 T: 3.4-3.8 L/mmol.S (slightly lower than other extracellular contrast agents)
  • concentration: 0.5 mmol/mL
  • recommended dosage: 0.1 mmol/kg

It is considered a high-stability agent, and is considered a good choice for patients with lower GFRs (see: nephrogenic systemic fibrosis)

It is also licensed in Europe and Australia for intra-articular use, when it is sold in prefilled syringes as Artirem, which is chemically identical to Dotarem.  It is not licensed for this use in North America.

Indications