Good syndrome

Good syndrome is a rare paraneoplastic syndrome in which a thymoma causes hypogammaglobulinemia and humoral immunodeficiency. It has been estimated to occur in 0.2%–2% of thymomas .

• thymoma
• low to absent B-cells
• T-cell mediated defects
  • CD4 T-cell lymphopenia
  • inverted CD4/CD8+ T-cell ratio

Patients with Good syndrome are highly susceptible to bacterial infections. Radiologically, patients with a thymoma may present with findings compatible with immunodeficiency, such as chronic lung disease.

History and etymology

Good syndrome was first described by Robert "Bob" Alan Good, (1922-2003) an American immunologist, in 1955 .

Siehe auch:

• Thymom

und weiter:

• Immundefektsyndrome