granular cell tumor

Mimickers of
breast malignancy: imaging findings, pathologic concordance and clinical management. Granular cell tumor. A 65-year-old woman presented for further evaluation of a focal asymmetry detected on screening mammopgrahy. Craniocaudal and lateral spot compression views (a, b) show a small irregular mass with spiculated margins (arrows). Color Doppler (c) and grayscale (d) ultrasound shows a corresponding irregular mass with internal vascularity (arrows). Core needle biopsy yielded granular cell tumor which was treated with surgical excision
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Granularzelltumor
der Speiseröhre in der Breischluckuntersuchung.
Wikipedia • CC BY-SA 3.0
Ovarian
granulosa cell tumour: MR imaging findings. Transverse T2-weighted image depicts inhomogeneous left adnexal mass (arrow), with signal intensity mainly similar to that of normal myometrium (not shown on this image), and small hyperintense areas, corresponding to internal cysts on pathology.
www.eurorad.org • CC by-nc-sa-4.0
Granular cell
tumors: a report of six cases. (a) Case 5. Ultrasonography revealed an irregularly bordered, low echoic tumor that protruded in a convex shape from the intrinsic muscle layer of the latissimus dorsi muscle. The size was 10 × 14 mm. (b) Case 6. Ultrasonography revealed a smoothly bordered tumor with posterior echo attenuation, having heterogeneous content and 18 × 17 mm in size.
wjso.biomedcentral.com • CC-by-2.0
nicht verwechseln mit: Granulosazelltumor
Radiopaedia • CC-by-nc-sa 3.0 • de

Granular cell tumors (GrCTs) are uncommon soft tissue tumors with the vast majority being benign (approximately 0.5-2.0% have been reported as malignant).

Pathology

They have been reported in all organ systems, but most prominently are found in these sites :

Microscopic appearance

Histologically, these tumors have a characteristic appearance. They are comprised of polygonal cells with bland nuclei and abundant eosinophilic granular cytoplasm. They are thought to be derived from neural tissue, as they stain positively for S-100 and neuron-specific enolase.

They are often classified as benign or malignant using the Fanburg-Smith criteria (especially for soft tissue lesions) . These histologic criteria include spindled cells, increased mitoses, necrosis, high nuclear to cytoplasmic ratio, nuclear pleomorphism, and prominent nucleoli. Lesions with 3 or more of these features are designated as malignant, 1 or 2 as atypical, and 0 as benign.

Treatment and prognosis

Although benign granular cell tumors have an excellent prognosis following wide local surgical excision to negative margins, malignant granular cell tumors portend dismal prognoses, as they both recur and metastasize often. Chemotherapy and radiotherapy have not yet proven helpful in treating malignant granular cell tumors .

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Assoziationen und Differentialdiagnosen zu Granularzelltumor:
Granularzelltumor
des Ösophagus
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Granularzelltumor
der Mamma
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