It is important to not confuse this syndrome with Löffler syndrome, as the names are quite similar but the conditions quite different.
Löfgren syndrome has a strong predominance for females in their thirties .
It typically consists of:
- constitutional symptoms
- erythema nodosum
- hilar lymphadenopathy: see thoracic manifestations of sarcoidosis
- symmetrical polyarthropathy
- most commonly affecting the ankles
- see musculoskeletal manifestations of sarcoidosis
- uveitis (occasionally)
- parotitis (occasionally)
Treatment and prognosis
Compared to run-of-the-mill sarcoidosis, patients presenting with Löfgren syndrome typically have a better overall prognosis with a self-limited clinical course (mean ~2 months ) and spontaneous remission.
History and etymology
It was initially described by Sven Halvar Löfgren (1910-1978), a Swedish physician, in 1952 .