Melkersson-Rosenthal syndrome (MRS), also known as cheilitis granulomatosa or Miescher-Melkersson-Rosenthal Syndrome, is a rare condition of unknown etiology characterized by:
- granulomatous inflammation of the face and lips (non-caseating)
- facial nerve (CN VII) paralysis (involvement of cranial nerves II, VIII, IX and XII have also been reported)
- plication of the tongue
All three findings are only seen in about 25% of cases, with orofacial edema being the dominant finding and presenting sign in 42% of cases.
The facial palsy in MRS, which typically occurs after the onset of edema (although preceding has been reported) is of the lower motor-neuron type and is seen in approximately 30% of patients. It may be complete or partial, unilateral or bilateral, transient or permanent.
Imaging findings are confined to confirming preseptal orbital edema.