muskuloskelettale Manifestationen Hämochromatose
Hemochromatosis is a systemic disease which affects many organs systems, including the joints, characterized by hemosiderin and calcium pyrophosphate deposition.
For a general discussion, and for links to other system specific manifestations, please refer to the article on hemochromatosis.
- chondrocalcinosis: particularly knees and triangular fibrocartilage
- symmetrical loss of joint space, subchondral cysts
- close association with CPPD which is often seen concurrently
- most commonly hands (MCP, carpal, PIP) with the characteristic hook like/ beak-like osteophytes projecting from radial ends of 2and 3metacarpals
more extensive involvement from the second to the fifth MCP and radial hook-like/drooping osteophytes are more characteristic than in CPPD
- can also affect the knee, hip, and elbow
- generalized osteoporosis (~25%) or osteopaenia (~40%)
On imaging consider:
- calcium pyrophosphate deposition disease (CPPD)
- distal hand joints rather than MCP joints
- psoriatic arthritis