Myo-inositol peak

Myo-inositol is one of the compounds images with MR spectroscopy (MRS) at both 1.5 T and 3 T and is seen to resonate at 3.5 ppm chemical shift (right of the choline peak).

Myo-inositol is a precursor of both phosphatidylinositol (the major inositol-containing phospholipid) and phosphatidylinositol 4,5-bisphosphate (a key molecule in cellular signal transduction). It also plays an important role in osmoregulation .

• elevated in
  • low-grade astrocytoma
  • progressive multifocal leukoencephalopathy (PML)
  • Alzheimer disease
  • Down syndrome 
  • regions of gliosis 
    • congenital CMV infection
    • subacute sclerosing panencephalitis
• reduced in
  • hepatic encephalopathy
  • glioblastoma (WHO grade IV astrocytoma) 

Siehe auch:

• MR spectroscopy
• Down-Syndrom
• Progressive multifokale Leukenzephalopathie
• Hepatische Enzephalopathie
• connatale Zytomegalie

und weiter:

• choline:creatine ratio