OEIS complex

The OEIS complex refers to the combined occurrence of:

• an omphalocele
• bladder exstrophy / cloacal exstrophy
• an imperforate anus
• and spinal anomalies: e.g
  • kyphoscoliosis
  • hemivertebrae

Epidemiology

The estimated occurrence is at around 1-200,000 to 400,000 live births .

Pathology

Possible embryologic mechanisms proposed for these findings include

• a single defect of early blastogenesis or 
• a defect of mesodermal migration during the primitive streak period

Associations

• renal anomalies

Markers

• maternal serum alpha-fetoprotein levels are markedly elevated

Siehe auch:

• Analatresie
• Blasenekstrophie
• Halbwirbel
• Omphalozele
• Kloakenekstrophie
• maternal serum alpha feto protein levels are markedly elevated

und weiter:

• angeborene Wirbelanomalien
• cyllosoma
• altered alpha fetoprotein levels
• kongenitale Bauchwanddefekte