POEMS syndrome
POEMS syndrome is the acronymic name for a rare multisystem paraneoplastic disorder comprising of a minimum of three of the following features in the setting of a plasma cell dyscrasia:
- P: polyneuropathy
- O: organomegaly
- E: endocrinopathy
- diabetes mellitus, amenorrhea, gynecomastia, hypothyroidism, hypoadrenalism, erectile dysfunction
- M: monoclonal gammopathy
- most commonly IgA lambda
- S: skin changes (including hyperpigmentation and skin thickening)
Associations
POEMS occurs in the setting of plasma cell dyscrasias such as osteosclerotic myeloma or plasmacytoma. There is an overlap with multicentric Castleman disease .
See also
- POEM procedure: unrelated procedure involving a esophageal myomectomy
Siehe auch:
und weiter:
Assoziationen und Differentialdiagnosen zu POEMS syndrome:
