The SAPHO syndrome is an acronym that refers to a rare syndrome that is manifested by a combined occurrence of :
It classically tends to present in young to middle-aged adults. Presentation in the pediatric population is not uncommon.
SAPHO and related conditions have three stages of progression, which are described as:
Plain radiograph is non-specific, but SAPHO syndrome can be suspected if present with the other clinical findings:
- sternoclavicular joint: most common location of involvement, with osteitis and hyperostosis
- osteosclerosis of vertebral bodies
- long bones: metaphyseal osteosclerosis and osteolysis
Treatment and prognosis
Tends to be benign although patients may have recurrent bouts of attacks. Pamidronate therapy has been successfully trialled for symptom relief (especially in the pediatric population) .
History and etymology
Chamot et al. initially described it in 1987 .