Kupfermangel
Toddler with
a dietary deficiency. AP radiograph of the knee shows metaphyseal cupping in the distal femur.The diagnosis was copper deficiency.
Location,
length, and enhancement: systematic approach to differentiating intramedullary spinal cord lesions. Subacute combined degeneration due to copper deficiency. A 45-year-old female with tingling in the bilateral upper and lower extremities. a Axial T2 image shows hyperintensity in the dorsal columns in an ‘inverted-V’ configuration (arrow). b Sagittal T2 image demonstrates long-segment T2 hyperintensity within the dorsal cord (bracket)
Copper deficiency (also known as hypocupremia) is unusual due to the ubiquity of copper in the normal diet.
Epidemiology
Copper deficiency is thought to be rare, but exact numbers are difficult to ascertain.
Clinical presentation
The typical presentation of copper deficiency mimics the more common vitamin B12 deficiency, which will usually need to be excluded first.
- blood dyscrasias e.g. anemia, leukopenia, thrombocytopenia
- neurotoxicity e.g. neuropathy, myelopathy, visual impairment
Pathology
Etiology
- artificial alimentation e.g. total parenteral nutrition, chronic tubal feeding
- post-surgical e.g. post-gastrectomy, bariatric surgery
- excessive zinc intake
- alcoholism (rare)
Radiographic features
Copper deficiency myeloneuropathy may produce identical neuroradiological findings to subacute combined degeneration of the cord and therefore be indistinguishable.
Treatment and prognosis
Cocoa is often trialled initially as it contains copper naturally in reasonable amounts and is palatable to the patient . In cases where gastrointestinal dysfunction is the underlying issue then intravenous copper administration may be required.
Siehe auch:
- Funikuläre Myelose
- Menkes-Syndrom
- Optikusatrophie
- Myelodysplastisches Syndrom
- Kupfermangel assoziierte Myelopathie
- periphere Neuropathie
und weiter:
Assoziationen und Differentialdiagnosen zu Kupfermangel:
