Hyperostosis frontalis interna
Hyperostosis frontalis interna is characterized by benign overgrowth of the inner table of the frontal bone. The etiology is unknown. The condition is generally of no clinical significance and an incidental finding. It is typically bilateral and symmetrical and may extend to involve the parietal bones. The skull thickening may be sessile or nodular, and may affect the bone in a focal or diffuse manner.
The importance of this condition stems mainly from the necessity of not mistaking it for pathology (see below).
Hyperostosis calvariae diffusa and hyperostosis frontoparietalis are related entities.
Epidemiology
Post mortem studies report a prevalence of 12% . It is most common in women over the age of 65 with 87% of severe hyperostosis frontalis interna occurring in this cohort of patients .
Clinical presentation
As hyperostosis frontalis interna is usually an incidental finding of no clinical significance patients are generally asymptomatic. Compression by calvarial thickening may lead to cerebral atrophy and may present with cognitive impairment, neuropsychiatric symptoms, headaches and epilepsy .
Pathology
The etiology and pathogenesis are not well understood although many theories have been proposed. These include a genetic predisposition, angiosomes of numerous vascular anastomoses on the frontal bone of the calvaria and the estrogen theory . Nodular endocranial remodeling may result in compression of the cerebrum.
Classification
Hyperostosis frontalis interna is classified into four grades of severity based on Hershkovitz's morphological and histopathological findings . The Hershkovitz classification was modified to include a fifth grade of severity after a cadaveric study in 2011 described hyperostotic findings at the falx cerebri .
- type A: endocranial frontal bone elevations less than 10 mm in diameter
- type B: nodular bony formations occupying less than 25% of the frontal bone
- type C: nodular bony formations occupying up to 50% of the frontal bone
- type D: continuous nodular bony formations involving more than 50% of the frontal endocranium
- type E: severe hyperostosis frontalis interna with soft tissue expansion
History and etymology
It was first described in 1719 by Morgagni as a pathology accompanying virilism and obesity .
Associations
It is part of the triad of Morgagni syndrome and may be encountered in a number of other syndromes :
- Troell-Junet syndrome
- Frölich syndrome
- Klippel-Trénaunay-Weber syndrome
Differential Diagnosis
The differential is that of hyperostosis of the skull and includes:
- Paget disease
- fibrous dysplasia
- sclerotic metastases
- meningioma
- acromegaly
- bone marrow pathology
Siehe auch:
- osteoblastische Knochenmetastasen
- Meningeom
- Fibröse Dysplasie
- Akromegalie
- Hyperostosis Kalotte
- Hyperostosis frontoparietalis
- Verdickungen der Schädelkalotte
- Morbus Paget der Kalotte
- Morgagni syndrome
und weiter:
Assoziationen und Differentialdiagnosen zu Hyperostosis frontalis interna:
