gastrointestinal leiomyosarcoma
Leiomyosarkome des Gastrointestinaltraktes
gastrointestinal leiomyosarcoma
Leiomyosarkom Radiopaedia • CC-by-nc-sa 3.0 • de
Leiomyosarcomas are extremely rare malignant neoplasms that originate from smooth muscle cells and may be considered the malignant counterpart of a leiomyoma. They are classified as a soft tissue tumor and account for ~8% of malignant soft tissue tumors .
Pathology
Location
Leiomyosarcomas can potentially occur anywhere where there is smooth muscle. Commonly described sites include the following:
- uterus: uterine leiomyosarcoma: most common (account for up to one-third of uterine sarcomas )
- retroperitoneum: retroperitoneal leiomyosarcoma; most common non-uterine site
- stomach: gastric leiomyosarcoma
- esophagus : esophageal leiomyosarcoma
- small intestine: leiomyosarcoma of the small intestine
- liver: hepatic leiomyosarcoma
- bladder
- nasopharynx
- bone: primary leiomyosarcoma of bone
- venous structures
- central nervous system: primary intracranial leiomyosarcoma
Other sites include
- spermatic cord: spermatic cord leiomyosarcoma
- pulmonary artery: primary pulmonary artery leiomyosarcoma
Radiographic features
Morphological imaging features would be invariably dependent on the site (refer to individual articles). Generally, they tend to be large masses, especially with abdominopelvic lesions.
CT
- generally heterogeneous
- commonly demonstrate central low attenuation representing necrosis
- calcification exceedingly rare
MRI
The tumor frequently demonstrates cystic foci. Signal characteristics include
- T1: isointense to muscle
- T2 non-fat suppressed: intermediate to hypointense to neighboring fat
- T2 FS: predominantly hyperintense
Differential diagnosis
For a meaningful differential, it is necessary to consider site-specific tumors.
Siehe auch:
- Leiomyosarkom
- gastrointestinal stromal tumors - leiomyoma/leiomyosarcoma
- Leiomyome des Gastrointestinaltraktes
- Leiomyosarkom des Kolons
- Leiomyosarkom des Dünndarms