WHO classification of tumors of soft tissue
The World Health Organization (WHO) classification of soft tissue tumors is the most widely used pathologic classification system for such disorders. The current revision, part of the 4 edition of the WHO series, was published in 2013 and is reflected in the article below .
Classification
Adipocytic tumors
- lipoma
- lipomatosis
- lipomatosis of nerve
- lipoblastoma
- angiolipoma
- myolipoma of soft tissue
- chondroid lipoma
- spindle cell/pleomorphic lipoma
- hibernoma
- atypical lipomatous tumor (well-differentiated liposarcoma)
- dedifferentiated liposarcoma
- myxoid liposarcoma
- pleomorphic liposarcoma
Fibroblastic/myofibroblastic tumors
- nodular fasciitis
- proliferative fasciitis and proliferative myositis
- myositis ossificans and fibro-osseous pseudotumor of digits
- ischemic fasciitis
- elastofibroma
- fibrous hamartoma of infancy
- fibromatosis colli
- juvenile hyaline fibromatosis
- inclusion body fibromatosis
- fibroma of tendon sheath
- desmoplastic fibroblastoma
- mammary-type myofibroblastoma
- calcifying aponeurotic fibroma
- angiomyofibroblastoma
- cellular angiofibroma
- nuchal-type fibroma
- Gardner fibroma
- calcifying fibrous tumor
- palmar/plantar fibromatosis
- desmoid-type fibromatosis
- lipofibromatosis
- giant cell fibroblastoma
- dermatofibrosarcoma protuberans
- extrapleural solitary fibrous tumor
- inflammatory myofibroblastic tumor
- low-grade myofibroblastic sarcoma
- myxoinflammatory fibroblastic sarcoma
- infantile fibrosarcoma
- adult fibrosarcoma
- myxofibrosarcoma
- low-grade fibromyxoid sarcoma
- sclerosing epithelioid fibrosarcoma
So-called fibrohistiocytic tumors
- tenosynovial giant cell tumor, localized type
- tenosynovial giant cell tumor, diffuse type
- deep benign fibrous histiocytoma
- plexiform fibrohistiocytic tumor
- giant cell tumor of soft tissue
Smooth muscle tumors
- leiomyoma of deep soft tissue
- leiomyosarcoma
Pericytic (perivascular) tumors
- glomus tumors
- myopericytoma, including myofibroma
- angioleiomyoma
Skeletal-muscle tumors
- rhabdomyoma
- embryonal rhabdomyosarcoma
- alveolar rhabdomyosarcoma
- pleomorphic rhabdomyosarcoma
- spindle cell/sclerosing rhabdomyosarcoma
Vascular tumors
- hemangiomas
- epithelioid hemangioma
- angiomatosis
- lymphangioma
- Kaposiform hemangioendothelioma
- retiform hemangioendothelioma
- papillary intralymphatic angioendothelioma
- composite hemangioendothelioma
- Kaposi sarcoma
- pseudomyogenic hemangioendothelioma
- other intermediate vascular neoplasms
- epithelioid hemangioendothelioma
- angiosarcoma of soft tissue
Chondro-osseous tumors
- soft-tissue chondroma
- extraskeletal osteosarcoma
Gastrointestinal stromal tumors
Nerve sheath tumors
- schwannoma (including variants)
- melanotic schwannoma
- neurofibroma (including variants)
- perineurioma
- granular cell tumor
- dermal nerve sheath myxoma
- solitary circumscribed neuroma
- ectopic meningioma/meningothelial hamartoma
- nasal glial heterotopia
- benign Triton tumor
- hybrid nerve sheath tumors
- malignant peripheral nerve sheath tumor
- malignant granular cell tumor
- ectomesenchymoma
Tumors of uncertain differentiation
- acral fibromyxoma
- intramuscular myxoma
- juxta-articular myxoma
- deep ("aggressive") angiomyxoma
- pleomorphic hyalinizing angiectatic tumor of soft parts
- ectopic hamartomatous thymoma
- atypical fibroxanthoma
- angiomatoid fibrous histiocytoma
- ossifying fibromyxoid tumor
- myoepithelioma/myoepithelial carcinoma/mixed tumor
- haemosiderotic fibrolipomatous tumor
- phosphaturic mesenchymal tumor
- synovial sarcoma
- epithelioid sarcoma
- alveolar soft part sarcoma
- clear cell sarcoma of soft tissue
- extraskeletal myxoid chondrosarcoma
- malignant mesenchymoma
- desmoplastic small round cell tumor
- extrarenal rhabdoid tumor
- PEComa
- intimal sarcoma
Undifferentiated/unclassified sarcomas
- spindle cell, pleomorphic, round cell, or epithelioid
Changes from prior versions
Compared to the 3edition of the WHO classification, published in 2002, the 4 edition had several major changes . Newly included entities were gastrointestinal stromal tumors, peripheral nerve sheath tumors, giant cell fibroblastoma, and dermatofibrosarcoma protuberans. Pleomorphic malignant fibrohistiocytoma and undifferentiated pleomorphic sarcoma were changed to the new category of undifferentiated/unclassified tumors. The mixed and round subtypes of liposarcoma were deleted, as was hemangiopericytoma.
Siehe auch:
- Lipom
- Myositis ossificans
- Liposarkom
- myxofibrosarcoma
- Paragangliom
- Pleomorphes Undifferenziertes Sarkom
- Synovialsarkom
- Leiomyosarkom
- Kavernom
- Fibromatosis colli
- inflammatorischer Pseudotumor
- Lymphangiom
- epitheloides Hämangioendotheliom
- Weichteilsarkom
- solitärer fibröser Tumor
- mesenchymal chondrosarcoma
- Hibernom
- Fasciitis nodularis
- alveolar rhabdomyosarcoma
- myoepithelioma
- Riesenzelltumor der Sehnenscheiden
- embryonales Rhabdomyosarkom
- pleomorphic rhabdomyosarcoma
- Parachordom
- Kaposisarkom
- pPNET
- angiosarcoma of soft tissue
- plantar
- botryoid
- synoviales Hämangiohamartom
- Angiomyxom
und weiter:
Assoziationen und Differentialdiagnosen zu Soft tissue tumors (WHO classification):
