Granulomatose mit Polyangiitis renale Manifestationen

The renal manifestations of granulomatosis with polyangiitis (GPA) are occult on imaging, especially when compared to the pulmonary changes.

For a general discussion of the condition, please refer to the main article on granulomatosis with polyangiitis (GPA). For other organ-specific radiographic features, please refer to individual articles:

• granulomatosis with polyangiitis: pulmonary manifestations
• granulomatosis with polyangiitis: upper respiratory tract manifestations
• granulomatosis with polyangiitis: CNS manifestations
• granulomatosis with polyangiitis: orbital manifestations

​Granulomatosis with polyangiitis (previously known as Wegener granulomatosis), is a multi-system systemic necrotizing non-caseating granulomatous vasculitis affecting small to medium-sized arteries, capillaries and veins.

Epidemiology 

Approximately half of GPA patients have kidney disease at presentation.

Clinical presentation

Reduced renal function, proteinuria and hematuria.

Pathology

GPA affects the kidneys with the development of necrotizing glomerulonephritis in ~60% (range 39-80%) of patients.

Siehe auch:

• Granulomatose mit Polyangiitis
• Nephritis