Multiple endocrine neoplasia type IV

Multiple endocrine neoplasia type IV (MEN4), previously known as MENX, is a rare type of MEN with clinical overlap with MEN1 but is due to a CKDN1B​ mutation. It is characterized by :

• parathyroid adenoma
  • primary hyperparathyroidism in 80%
• anterior pituitary adenoma
• neuroendocrine tumors (pulmonary, gastrointestinal, pancreatic)
• associated with other tumors of the reproductive tract, adrenal glands and kidneys

See also

• MEN1 (Wermer syndrome)
• MEN2 (multiple endocrine adenomatosis)
  • MEN2a (Sipple syndrome)
  • MEN2b (mucosal neuroma syndrome)
  • familial medullary thyroid carcinoma
• MEN4
• Carney complex