Nodule-in-nodule appearance (liver)

In hepatic imaging, a nodule-in-nodule appearance represents foci of abnormal arterial enhancement within a liver lesion, in cases of a liver regenerative nodule with a focus of hepatocellular carcinoma or high-grade dysplastic nodule. It is so called because of the nodular arterial enhancement is seen within the main non-enhancing liver nodule (at least in arterial phase).

It may be seen in up to 6% of patients with dysplastic nodules .