Diffuse bony sclerosis
Osteopetrosis.
ADO: lateral spine radiograph, age 4 years. Note sclerosis of vertebral endplates (arrows) resulting in "sandwich vertebrae" appearance.
Paget disease
(bone) • Paget disease of the skull - Ganzer Fall bei Radiopaedia
Preschooler
with short stature. AP and lateral radiographs of the skull (above) and axial CT without contrast of the brain (below) shows diffusely sclerotic skull bones with a thickened diploic space and diastatis of the coronal and lambdoid and sagittal sutures.The diagnosis was pyknodysostosis.
Generalized
increased bone density in adults • Systemic mastocytosis - Ganzer Fall bei Radiopaedia
Systemic
mastocytosis. Abdominal X-ray showed diffuse sclerosis of the lumbar vertebrae, sacrum, iliac and femoral heads.
Thoracic
myelopathy caused by ossification of ligamentum flavum of which fluorosis as an etiology factor. Anteroposterior view radiograph of both forearms showed significant calcifications of interosseous membranes of forearm.
Osteopoikilosis.
Shoulder joint radiographs detected elliptic and longitudinal sclerotic bone lesions in epiphyseal and metaphyseal region of proximal humeral bones, distal clavicles and scapulae.
The causes of generalized increase in bone density in adult patients, also known as generalized or diffuse osteosclerosis, can be divided according to broad categories:
- hematological disorders
- myelosclerosis
- marrow cavity is narrowed by endosteal new bone
- patchy lucencies due to the persistence of fibrous tissue (generalized osteopenia in the early stages due to myelofibrosis)
- hepatosplenomegaly
- sickle cell disease
- osteosclerosing multiple myeloma
- myelosclerosis
- metabolic
- poisoning
- fluorosis
- with periosteal reaction, prominent muscle attachments and calcification of ligaments and interosseous membranes
- changes are most marked in the innominate bones and lumbar spine
- fluorosis
- neoplastic (more commonly multifocal than generalized)
- malignancy
- osteoblastic metastases: most commonly prostate and breasts
- lymphoma: infiltrative
- leukemia: infiltrative
- mastocytosis
- sclerosis of marrow-containing skeleton with patchy areas of radiolucency
- urticaria pigmentosa
- can have symptoms and signs of carcinoid syndrome
- idiopathic (more commonly multifocal than generalized)
- Paget disease: coarsened trabeculae, bony expansion and thickened cortex
- congenital: sclerosing bone dysplasias
- other
- hepatitis C associated osteosclerosis (HCAO)
There are several mnemonics for dense bones.
See also
Siehe auch:
- osteoblastische Knochenmetastasen
- diffuse bony sclerosis (mnemonic)
- Morbus Paget des Knochens
- Osteopoikilose
- Osteomyelofibrose
- Sichelzellenanämie
- Osteopetrose
- Renale Osteodystrophie
- Adenokarzinom der Prostata
- Pyknodysostose
- Fluorose
- Melorheostose
- Mastozytose
- Osteopathia striata
- sekundärer Knochenbefall bei Lymphom
- Leukämie
- osteomesopyknosis
- differential diagnosis of generalised increased bone density in adults
- sclerosing bony dysplasias
und weiter:
Assoziationen und Differentialdiagnosen zu diffuse skelettale Sklerosierung: 
