Fetales Warfarinsyndrom
Fetal warfarin syndrome (FWS) is a rare condition which can occur as a result of fetal exposure to maternal ingestion of warfarin during pregnancy.
Clinical presentation
Reported clinical features include:
- facial anomalies
- nasal bone hypoplasia
- nasal bridge depression
- skeletal anomalies
- stippled non-calcified epiphyses
- shortened fingers: brachydactyly
- nail hypoplasia
- scoliosis
- central nervous system
- intellectual disability
- seizures
- ventriculomegaly
- agenesis of corpus callosum
- microcephaly
- microphthalmia
- congenital cataracts
- cardiovascular
Pathology
Warfarin is a teratogenic drug. The increased risk of birth defects occurs particularly with warfarin use during ~6-9 weeks gestation.
Differential diagnosis
- some features (particularly skeletal) can mimic that of chondrodysplasia punctata
Siehe auch:
- Chondrodysplasia punctata
- Keutel-Syndrom
- Mittelgesichtshypoplasie
- Warfarin
- Hereditärer kombinierter Mangel an Vitamin K-abhängigen Gerinnungsfaktoren
- Chondrodysplasie mit Brachytelephalangie
und weiter:
Assoziationen und Differentialdiagnosen zu Fetales Warfarinsyndrom:
