It typically occurs in women and in an older age group than papillary (i.e. 40-60 years of age).
Unlike papillary, it metastasizes late to lymph nodes, with only 5-10% of patients having nodal metastases at the time of diagnosis. Haematogenous spread is however much more common with 20% or so of patients having distant haematogenous metastases at presentation.
The Ras oncogene is positive in a significant proportion of individuals.
- classic follicular thyroid carcinoma
- insular variant
- lesions are typically hypoechoic
- usually lacks cystic change
Follicular thyroid cancer typically concentrates pertechnetate, but not radioiodine.
Treatment and prognosis
Treatment tends to revolve around local surgical treatment and radioactive iodine.
Prognosis is not as favorable as papillary, but better than anaplastic, and depends on the presence and extent of distal metastatic disease. In local disease, 90% 10-year survival can be expected, whereas with a distant disease that figure drops to approximately 50%.
Differentiation of follicular carcinoma from follicular adenoma of the thyroid cannot be made on cytology alone and requires examination of the surgical specimen looking for extracapsular spread.
- papilläres Schilddrüsenkarzinom
- ACR TI-RADS scoring system
- Medulläres Schilddrüsenkarzinom
- Neoplasien der Schilddrüse
- anaplastisches Schilddrüsenkarzinom
- follikuläres Adenom der Schilddrüse
- papillary cancer
- follikuläre Variante des papillären Schilddrüsenkarzinoms