Hoffa fat pad ganglion cyst

Hoffa fat pad ganglion cysts are intra-articular ganglion cysts, are the most common mass-like lesions within Hoffa’s fat pad and represent one type of many cyst-like lesions around the knee.

Epidemiology

Hoffa fat pad ganglion cysts are rare and less common than cruciate ligament ganglion cysts .

Clinical presentation

Ganglia within Hoffa’s fat pad can be asymptomatic or can cause pain and swelling or present as a palpable mass .

Pathology

Ganglion cysts within Hoffa’s fat pad are usually well-defined, smooth-walled, uni- or multilocular, lobulated cystic masses surrounded by dense connective tissue and filled with viscous, mucinous material like other ganglion cysts. They lack a synovial membrane .

Etiology

Like with other ganglion cysts the pathogenesis is controversial and comprises the following theories :

  • a sequel of mucoid degeneration
  • cyst formation as a consequence of trauma or tissue irritation
  • release of hyaluronic acid by mesenchymal stem cells and consecutive cyst formation
  • synovial herniation
  • congenital translocation of synovial cells
Location

Ganglion cysts of Hoffa’s fat pad are usually located anterior to the anterior horn of the lateral meniscus .

Radiographic features

MRI

MRI is the best modality for the visualization and evaluation of intra-articular ganglion cysts. The typical appearance is that of a well-defined lobular cystic mass within or adjacent to the Hoffa’s fat pad .

  • T1: usually hypointense but will depend on protein content
  • T2: hyperintense
  • PDFS/T2FS: hyperintense

Treatment and prognosis

Management options depend vastly on clinical symptoms and include conservative measures, image-guided percutaneous aspiration as well as arthroscopic or surgical excision .

Differential diagnosis

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