hypogammaglobulinaemia

Hypogammaglobulinaemia is an immune disorder characterized by a reduction in all types of gammaglobulins.

Terminology

While hypogammaglobulinaemia means some of loss of gammaglobulins, a total loss is termed agammaglobulinaemia which can occur in as an x linked form - X-linked agammaglobulinemia.

Clinical presentation

The most commonly recognized clinical feature is recurrent infection (often respiratory). Increased incidence of parasitic gastrointestinal infections may also be present.

Pathology

Causes

It may be primary of acquired.

Primary
Acquired
Other associations
Serology

There are decreased levels of immunoglobulins (especially IgG)

Radiographic features

Features secondary to recurrent bronchopulmonary and sinus infections are common

These include

Thorax
Abdomen