Klinodaktylie

Clinodactyly is a descriptive term that refers to a radial angulation at an interphalangeal joint in the radio-ulnar or palmar planes. It typically affects the 5 finger.

Epidemiology 

The estimated incidence is highly variable dependent on sampling and has been reported to range between 1-18%.

Pathology 

Clinodactly can result from vast number pathologies ranging from congenital to acquired.

Genetics 

As well as being sporadic, it can run in families with an autosomal recessive inheritance.

Associations

Although clinodactyly is often an isolated phenomenon and can be even a normal variant, there are numerous described associations which include:

• aneuploidic syndromic
  • Down syndrome: may be seen in up to 60% of infants with Down syndrome
  • Klinefelter syndrome
  • trisomy 18
  • Turner syndrome
• non aneupliodic syndromic
  • Cornelia de Lange syndrome
  • Feingold syndrome
  • Roberts syndrome
  • Russell-Silver syndrome
  • Fanconi anemia
• non syndromic
  • macrodystrophia lipomatosa
  • brachydactyly type A3

Significance

Due to its association with chromosomal anomalies, it is considered by some authorities as a "soft sign" if detected in an antenatal ultrasound scan .

Prognosis

If detected in isolation it carries an excellent prognosis.

See also

• Kirner deformity

Siehe auch:

• Brachydaktylie
• Down-Syndrom
• macrodystrophia lipomatosa
• Turner-Syndrom
• Trisomie 18
• Roberts-Syndrom
• Cornelia-de-Lange-Syndrom
• Feingold syndrome
• Fanconi-Anämie
• Klinefelter-Syndrom
• Russell-Silver syndrome
• Mutchinick-Syndrom
• Kirner's deformity

und weiter:

• obstetric curriculum
• Meckel-Syndrom
• Akrorenales Syndrom
• dysencephalia spanchnocystica
• Kabuki-Syndrom
• Rubinstein-Taybi-Syndrom
• Kirner deformity
• kongenitale Anomalien der Finger
• Russell-Silver dwarfism
• soft antenatal markers on ultrasound
• Stenose der Apertura piriformis
• Catel-Manzke-Syndrom
• SHORT syndrome
• Polysyndaktylie
• Pseudoaminopterin-Syndrom