Glaskörperblutung

Ocular
cysticercosis with vitreous hemorrhage: a rare complication of a common disease. Ocular B-scan ultrasonography (a) showing septations and debris in vitreous on both sides. There is cystic area with small peripheral solid nodular area in subretinal space in both eyes (right and left eyes). [Arrows] Gross examination of pathological specimen revealed a thin walled, transparent, globular cyst with eccentrically placed small scolex (b). [Arrow] Magnetic resonance imaging (MRI) of orbit showing V-shape retinal detachment in posterior chamber of left globe. Heterogeneous hyperintense signal is seen in posterior chamber of right globe (c, d) [Arrows].
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Ocular
ultrasonography focused on the posterior eye segment: what radiologists should know. Acute and chronic vitreous haemorrhage in two different patients. a 72-year-old man with history of diabetes mellitus who presented with sudden blurred vision due to acute vitreous haemorrhage. At US, subtle echogenic material that obscured the ophthalmoscopic examination is seen floating within the vitreous. b Axial US image in a 58-year-old man with a history of vitreous haemorrhage 4 months earlier shows echogenic bands in the vitreous representing fibrous membranes, characteristic of chronic vitreous haemorrhage. The patient went on to undergo vitrectomy
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Vitreous hemorrhage refers to bleeding into the vitreous humor.

Epidemiology

Vitreous hemorrhage has an incidence of approximately 7 in 100000 .

Clinical presentation

The most common clinical presentation is with sudden, painless visual loss to varying degrees of severity . Associated ‘floaters’ or shadows in the vision have also been reported . In traumatic cases, orbital pain may be present, although this is likely to be due to other orbital injuries rather than the vitreous hemorrhage itself .

Slit-lamp examination confirms the diagnosis through visualization of blood in the vitreous chamber, although may have a limited role in detecting the underlying cause if the hemorrhage is diffuse .

Pathology

The vast majority of vitreous hemorrhage occurs secondary to proliferative diabetic retinopathy, posterior vitreous detachment, retinal detachment or tear (which in itself could be due to posterior vitreous detachment or proliferative diabetic retinopathy, among other causes), orbital trauma, or ocular malignancy  . However, in a broader sense, bleeding into the vitreous chamber occurs through two main mechanisms:

  • rupture of normal vessels via mechanical forces: posterior vitreous detachment, retinal detachment or retinal tear, closed or open orbital trauma, non-accidental injury (shaken baby syndrome), Terson syndrome 
  • pathological rupture of vessels: proliferative diabetic retinopathy, wet age-related macular degeneration, others causes of neovascularization, ocular malignancy

    • Radiographic features

    Ultrasound

    Both A-scan and contact B-scan (more useful) ultrasound have a role in confirming the vitreous hemorrhage and also detecting underlying causes such as posterior vitreous detachment, retinal detachment or tear, trauma, or malignancy .

    Findings with B-mode ultrasonography depend on both the severity of the hemorrhage and the time elapsed since the hemorrhage occurred ;

    • acute vitreous hemorrhage
      • scattered, ill-defined collections of slightly echogenic opacities
        • often requires considerable increase in gain to visualize
      • demonstrate mobility with extraocular movements
    • subacute to chronic vitreous hemorrhage
      • organization into more echogenic membranous structures
        • when severe may obliterate vitreous body as a confluent, echogenic hematoma
      • retains mobility with eye movements
        • mobility declines with age of hemorrhage
    CT

    Hemorrhage usually demonstrates hyperattenuation, which may be either homogeneous or heterogeneous, in the vitreous chamber on CT . Similar to ultrasound, CT can also be utilized to detect underlying orbital pathologies, but has an advantage in also being able to detect extra-orbital pathologies such as subarachnoid hemorrhage (causing Terson syndrome) .

    MRI

    MRI is uncommonly performed but confirms findings seen on ultrasound and CT. Normally, the vitreous humor demonstrates T1 hypointensity and T2 hyperintensity . These normal signal characteristics are often not appreciated in cases of vitreous hemorrhage . The exact appearance of vitreous hemorrhage on MRI is very variable depending on the age of the blood (see aging blood on MRI), however gradient-recalled echo or susceptibility-weighted imaging are considered the most useful and sensitive sequences where the hemorrhage will demonstrate low signal .

    Treatment and prognosis

    Although spontaneous regression of the hemorrhage is seen in approximately half of all patients, the condition may require operative intervention with posterior vitrectomy . Treatment of the underlying cause is also paramount .

    Differential diagnosis

    In some situations consider

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