Eye of the tiger sign (globus pallidus)

Eye of the

tiger sign (globus pallidus) • Tiger eye (photo) - Ganzer Fall bei Radiopaedia

Hacking C, Tiger eye (photo). Case study, Radiopaedia.org (Accessed on 03 May 2024) https://doi.org/10.53347/rID-76521 • CC by-nc-sa 3.0 (modified)

Eye of the

tiger sign (globus pallidus) • Pantothenate kinase-associated neurodegeneration - Ganzer Fall bei Radiopaedia

Gandhi A, Pantothenate kinase-associated neurodegeneration. Case study, Radiopaedia.org (Accessed on 03 May 2024) https://doi.org/10.53347/rID-19830 • CC by-nc-sa 3.0 (modified)

Neurodegeneration

with brain iron accumulation • Pantothenate kinase-associated neurodegeneration - eye of the tiger sign - Ganzer Fall bei Radiopaedia

Kwong Y, Pantothenate kinase-associated neurodegeneration - eye of the tiger sign. Case study, Radiopaedia.org (Accessed on 19 Apr 2023) https://doi.org/10.53347/rID-41008 • CC by-nc-sa 3.0 (modified)

Eye of the

tiger sign (globus pallidus) • Pantothenate kinase-associated neurodegeneration - eye of the tiger sign - Ganzer Fall bei Radiopaedia

Al Khateeb A, Pantothenate kinase-associated neurodegeneration - eye of the tiger sign. Case study, Radiopaedia.org (Accessed on 03 May 2024) https://doi.org/10.53347/rID-45520 • CC by-nc-sa 3.0 (modified)

Eye of the

tiger sign (globus pallidus) • Pantothenate kinase-associated neurodegeneration - eye of the tiger sign - Ganzer Fall bei Radiopaedia

Ibrahim D, Pantothenate kinase-associated neurodegeneration - eye of the tiger sign. Case study, Radiopaedia.org (Accessed on 03 May 2024) https://doi.org/10.53347/rID-167046 • CC by-nc-sa 3.0 (modified)

Radiopaedia • CC-by-nc-sa 3.0 • de

The eye of the tiger sign refers to abnormal low T2 signal on MRI (due to abnormal accumulation of iron) in the globus pallidus with a longitudinal stripe of high signal (due to gliosis and spongiosis).

The eye of the tiger sign is most classically associated with pantothenate kinase-associated neurodegeneration although it is not pathognomonic . There are no formalized criteria for the sign and other conditions may demonstrate a similar appearance, such as Wilson disease , atypical parkinsonism and organophosphate poisoning ; it may also be a normal finding on a 3 T magnet . Therefore, caution should be used when interpreting this sign.