Gardner syndrome

Gardner syndrome is one of the polyposis syndromes. It is characterized by:

Other abnormalities include:

Pathology

There is an autosomal dominant inheritance in the FAP gene (chromosome 5q) in a majority of patients but with 20% of cases resulting from new mutations. Extracolonic features often precede the diagnosis of colonic polyps.

History and etymology

First described in 1953 by Gardner and Richards .