Temporallappenepilepsie

Temporal lobe epilepsy (TLE) is the most common type of partial epilepsy, with often characteristic imaging and clinical findings. It is divided into two broad groups:

  • medial epilepsy
  • lateral epilepsy
    • involves the inferolateral and lateral neocortex of the temporal lobe
  • Clinical presentation

    Patients with temporal lobe epilepsy demonstrate three phases, each of variable duration and symptomatology:

  • preictal (aura) phase
  • ictal phase
  • postictal phase
  • Pre-ictal phase

    A variable number of patients with temporal lobe epilepsy demonstrate or describe an aura, which is usually of short duration, and in most cases (70%) goes on to become a seizure . Auras are variable in symptomatology, and include:

    • viscerosensory aura
      • typically from lesions of the amygdala or insular cortex
    • psychic (experienced) aura
      • typically from limbic structures
      • variable including dysmnesic phenomena, cognoscitive phenomena, emotional phenomena, delusions, and hallucinations
    Ictal phase

    The majority of patients have a complex partial seizure, during which a number of relatively specific features may be observed:

    • automatisms
      • stereotyped motor behaviors, typically of the mouth or hands
      • seen in 40-80% of cases
    • language alterations
    • unilateral dystonic posturing
    • versive head turning
    Postictal phase

    Postictal phase is also variable, and symptoms are largely determined by the location of the ictal lesion. Features include:

    • confusion
    • drowsiness
    • aphasia
    • psychiatric symptoms

    Pathology

    Temporal lobe epilepsy may be due to a veritable menagerie of causes including :

    Radiographic features

    MRI is the modality of choice for structural imaging of the temporal lobe, and of course, appearances will depend on the underlying cause. These are discussed separately, thus please refer to:

    It is essential to review the whole scan carefully as there is a high (5-20%) incidence of dual pathology, especially in cases of cortical dysplasia.

    Treatment and prognosis

    It is established that chronic medication-resistant epilepsy developed during childhood is linked to cognitive compromise and thus an early aggressive treatment and seizure control is advised for infants and young children .

    Treatment depends on the etiology, but in most cases is primarily with antiepileptic medications. In refractory cases, especially when a causative lesion can be identified, temporal lobectomy can be effective, provided cases are carefully selected.

    Siehe auch:
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