Sickle cell disease (abdominal manifestations)

Computed tomography of the spleen: how to interpret the hypodense lesion. Transverse contrast-enhanced CT images acquired during the portal venous phase. a A 43-year-old man with advanced sickle-cell disease. Note the irregular shape of the spleen, as well as the increased density of the splenic parenchyma, together with extensive calcifications as a consequence of constantly occurring micro-infarctions. b A 38-year-old man with sickle-cell disease exhibiting end-stage splenic involvement. Note the increased density, calcifications of the shrunken spleen

Computed

tomography of the spleen: how to interpret the hypodense lesion. Transverse contrast-enhanced CT images acquired during the portal venous phase. a A 43-year-old man with advanced sickle-cell disease. Note the irregular shape of the spleen, as well as the increased density of the splenic parenchyma, together with extensive calcifications as a consequence of constantly occurring micro-infarctions. b A 38-year-old man with sickle-cell disease exhibiting end-stage splenic involvement. Note the increased density, calcifications of the shrunken spleen

insightsimaging.springeropen.com • CC-by-2.0

Imaging findings of splenic emergencies: a pictorial review. Splenic sequestration. (a) CT features of ASSC. Contrast-enhanced axial CT image of a 26-year-old male with known sickle cell-thalassemia reveals lack of enhancement in spleen parenchyma (arrow). Retrograde filling of splenic vein (arrowhead) from the portal vein can be visualized. (b) Axial T2-weighted MRI demonstrates hypointense spleen (arrows) secondary to iron deposition. Splenic vein manifests with hyperintense appearance (arrowheads) due to slow flow resulting from retrograde venous filling

Imaging

findings of splenic emergencies: a pictorial review. Splenic sequestration. (a) CT features of ASSC. Contrast-enhanced axial CT image of a 26-year-old male with known sickle cell-thalassemia reveals lack of enhancement in spleen parenchyma (arrow). Retrograde filling of splenic vein (arrowhead) from the portal vein can be visualized. (b) Axial T2-weighted MRI demonstrates hypointense spleen (arrows) secondary to iron deposition. Splenic vein manifests with hyperintense appearance (arrowheads) due to slow flow resulting from retrograde venous filling

insightsimaging.springeropen.com • Open Access

Sickle cell disease • Sickle cell disease - Ganzer Fall bei Radiopaedia

Sickle cell

disease • Sickle cell disease - Ganzer Fall bei Radiopaedia

Singh, G. Sickle cell disease. Case study, Radiopaedia.org. (accessed on 20 Oct 2022) https://doi.org/10.53347/rID-7731 • CC by-nc-sa 3.0 (modified)

Sickle cell disease (abdominal manifestations) • Sickle cell disease (abdominal manifestations) - Ganzer Fall bei Radiopaedia

Sickle cell

disease (abdominal manifestations) • Sickle cell disease (abdominal manifestations) - Ganzer Fall bei Radiopaedia

Ashraf A, Sickle cell disease (abdominal manifestations). Case study, Radiopaedia.org (Accessed on 17 Aug 2023) https://doi.org/10.53347/rID-91069 • CC by-nc-sa 3.0 (modified)

Sickle cell disease • Sickle cell disease - Ganzer Fall bei Radiopaedia

Sickle cell

disease • Sickle cell disease - Ganzer Fall bei Radiopaedia

Dixon, A. Sickle cell disease. Case study, Radiopaedia.org. (accessed on 20 Oct 2022) https://doi.org/10.53347/rID-10325 • CC by-nc-sa 3.0 (modified)

Gallstones • Cholelithiasis in sickle cell anemia - Ganzer Fall bei Radiopaedia

Gallstones

• Cholelithiasis in sickle cell anemia - Ganzer Fall bei Radiopaedia

Awal S, Cholelithiasis in sickle cell anemia. Case study, Radiopaedia.org (Accessed on 01 Jan 2023) https://doi.org/10.53347/rID-77869 • CC by-nc-sa 3.0 (modified)

Radiopaedia • CC-by-nc-sa 3.0 • de

siehe auch

Splenomegalie
Sichelzellenanämie
portale Hypertension
Autosplenektomie
Papillennekrose der Niere
muskuloskelettale Manifestationen bei Sichelzellanämie
Acute chest syndrome bei Sichelzellanämie
Cholelithiasis bei Sichelzellenanämie
Gallensteine bei Kindern
Sichelzellenanämie (zerebrale Manifestationen)
coarsened echotexture
Sichelzellenanämie (chronische Lungenerkrankung)

Abdominal manifestations of sickle cell disease (SCD) are wide and can involve many organs.

For a general discussion, please refer to sickle cell disease.

Splenic

splenomegaly
- may occur transiently with the sequestration syndrome, where rapid pooling of blood occurs in the spleen, resulting in intravascular volume depletion, with potential for cardiovascular collapse
autosplenectomy
- the slow, tortuous micro-circulation of the spleen renders it susceptible to infarction and subsequent functional asplenia
- 94% are asplenic by age 5
- radiological finding is of a small, calcified spleen
splenic abscesses

Hepatobiliary

hepatic iron deposition secondary to multiple transfusions
hepatomegaly +/- coarsened echotexture with portal hypertension
cholelithiasis +/- choledocholithiasis
multiple liver abscesses

Renal

kidneys are often large early in the disease, with variable echogenicity on ultrasound, but shrink with development of renal failure. Bilateral echogenic pyramids are frequently seen in sickle cell disease
renal papillary necrosis
renal vein thrombosis

Gastrointestinal tract

approximately 40% patient may develop peptic ulcers due to reduced mucosal resistance and bowel ischemia

Sickle cell disease (abdominal manifestations)

Splenic

Hepatobiliary

Renal

Gastrointestinal tract

See also

Siehe auch: