Cholelithiasis bei Sichelzellenanämie
Teenager with
sickle cell disease and abdominal pain. AXR AP (left) shows faint calcifications in the right upper quadrant, just beneath the tip of the 12th rib and at the level of the L2 vertebral body which are better demonstrated on the coronal CT without contrast of the abdomen which demonstrates 5 calcifications within the gallbladder.The diagnosis was cholelithiasis in a patient with sickle cell disease.
Teenager with
right upper quadrant pain and sickle cell disease. Sagittal (above) and transverse (below) US of the gallbladder show multiple small round echogenic mobile objects within the gallbladder that cause posterior shadowing.The diagnosis was cholelithiasis due to sickle cell disease.
Cholelithiasis bei Sichelzellenanämie
Sichelzellenanämie (abdominelle Manifestationen) Radiopaedia • CC-by-nc-sa 3.0 • de
Abdominal manifestations of sickle cell disease (SCD) are wide and can involve many organs.
For a general discussion, please refer to sickle cell disease.
Splenic
- splenomegaly
- may occur transiently with the sequestration syndrome, where rapid pooling of blood occurs in the spleen, resulting in intravascular volume depletion, with potential for cardiovascular collapse
- autosplenectomy
- the slow, tortuous micro-circulation of the spleen renders it susceptible to infarction and subsequent functional asplenia
- 94% are asplenic by age 5
- radiological finding is of a small, calcified spleen
- splenic abscesses
Hepatobiliary
- hepatic iron deposition secondary to multiple transfusions
- hepatomegaly +/- coarsened echotexture with portal hypertension
- cholelithiasis +/- choledocholithiasis
- multiple liver abscesses
Renal
- kidneys are often large early in the disease, with variable echogenicity on ultrasound, but shrink with development of renal failure. Bilateral echogenic pyramids are frequently seen in sickle cell disease
- renal papillary necrosis
- renal vein thrombosis
Gastrointestinal tract
- approximately 40% patient may develop peptic ulcers due to reduced mucosal resistance and bowel ischemia
See also
Siehe auch:
Assoziationen und Differentialdiagnosen zu Cholelithiasis bei Sichelzellenanämie:
