Choriocarcinoma is an aggressive, highly vascular tumor. When it is associated with gestation, it is often considered part of the spectrum of gestational trophoblastic disease; it is then termed gestational choriocarcinoma. When it occurs in the absence of preceding gestation, it is termed non-gestational choriocarcinoma (these occur most often in the ovary or testis).
Depends on the site of origin of the tumor. In females, it may occur during or outside of pregnancy; non-gestational choriocarcinoma of the ovary typically occurs in prepubertal girls and postmenopausal women. Testicular choriocarcinomas usually present in male patients between ages 15 and 30 .
In the classic case of gestational choriocarcinoma, the tumor is derived from chorionic epithelium.
Typically arises in association with reproductive organs:
- uterus: choriocarcinoma of the uterus
- ovary: choriocarcinoma of the ovary
- testes: testicular choriocarcinoma
Primary occurrence outside the reproductive system has been reported but is extremely rare. Such sites include:
- brain: primary intracranial choriocarcinoma
- lung: primary pulmonary choriocarcinoma (PPC)
- pulmonary arteries
- the small intestine
Trophoblastic cells have an affinity for blood vessels and therefore the tumors have a tendency to metastasize through the haematogenous route.
Choriocarcinoma is one of the causes of cannonball metastases to the lungs.
High levels of βhCG are usually seen in cases of choriocarcinoma.
Imaging features of a primary tumor are dependent on location: see individual subtypes under "location" above.
Treatment and prognosis
The tumor is aggressive in its behavior and metastases are frequent, with the lungs being a common site of metastasis. Despite its aggressiveness, it is generally highly chemosensitive and carries a much better cure rate than other comparable malignancies.
A significant proportion of the complications arises from hemorrhage due to high vascularity in either a primary tumor or its metastases.
- gestational trophoblastic disease
- testicular choriocarcinoma
- gestational choriocarcinoma
- pure primary ovarian choriocarcinoma
- non gestational choriocarcinoma
- choriocarcinoma of the uterus
- mediastinal choriocarcinoma
- choriocarcinoma of the ovary
- primär pulmonales Chorionkarzinom
- primary intracranial choriocarcinoma
- hypervaskularisierte Leberläsionen
- Tumoren des vorderen oberen Mediastinums
- differential diagnosis of calcified pulmonary densities
- CNS germinoma
- ultrasound appearances of liver metastases
- intracranial choriocarcinoma
- complete mole
- uterine choriocarcinoma
- classification of germ cell tumours
- non-seminomatous germ cell tumours
- choriocarcinoma staging
- haemorrhagic metastases (mnemonic)
- Neoplastic intracranial aneurysm
- germ cell tumours (mnemonic)
- germ cell tumour classification
- mediastinale Keimzelltumoren
- pure non gestational choriocarcinoma of the ovary
- chorioadenoma destruens
- Lungenmetastasen bei Chorionkarzinom
- nichtseminomatöser Keimzelltumor
- maligne Neoplasien des Hodens
- gynäkologisch radiologisches Curriculum